Tesofensine (250mcg) / Dihexa (10mg) x 60 Tablets
The Science
Overview
The tablet combines two compounds with distinct but complementary mechanisms studied in cognitive and metabolic research. Tesofensine is a serotonin / norepinephrine / dopamine reuptake inhibitor studied for appetite, energy expenditure, and motor effects. Dihexa is an angiotensin IV analog that mimics Hepatocyte Growth Factor (HGF) signaling and is studied for synaptogenesis and cognitive performance.
The 60-tablet research format supports longitudinal study of combined monoaminergic and growth-factor signaling on cognitive, motivational, and metabolic endpoints.
Distinct from the Brain Blend formulation, this two-active combination omits BPC-157 to isolate the tesofensine × dihexa interaction.
Laboratory Observations
Research-Observed Areas of Interest
Dual-Pathway Cognitive Research
Combines monoaminergic and growth-factor signaling in a single tablet for integrated cognitive and metabolic studies.
Synaptic Plasticity Endpoints
Dihexa's HGF-mimetic activity supports research into dendritic spine density and synaptic-plasticity markers.
Mechanism of Action
Mechanism of Action
Triple Monoamine Reuptake Inhibition
Tesofensine blocks reuptake of serotonin, norepinephrine, and dopamine, prolonging synaptic monoamine activity in pathways relevant to appetite, energy expenditure, and motivation research.
HGF-Mimetic Synaptogenesis
Dihexa engages HGF/c-Met signaling, supporting dendritic spine formation and synaptic plasticity in cognitive research models.
Combined Cognitive-Metabolic Signaling
The dual mechanism allows research designs that pair monoaminergic effects on attention and energy with growth-factor-driven synaptic remodeling.
FAQ
Frequently Asked Questions
How does this differ from the Brain Blend tablets?+
Brain Blend contains tesofensine, dihexa, and BPC-157. This formulation omits BPC-157 to isolate the tesofensine × dihexa combination for research models targeting that specific interaction.
What is dihexa?+
An angiotensin IV-derived peptidomimetic that crosses the blood-brain barrier and mimics Hepatocyte Growth Factor signaling — studied extensively for its effects on dendritic spine density and cognitive performance in research models.
What is tesofensine?+
A serotonin / norepinephrine / dopamine triple reuptake inhibitor originally investigated for neurodegenerative and metabolic indications, with research interest in appetite, energy expenditure, and motivation.
Research-Only Notice
Tesofensine (250mcg) / Dihexa (10mg) x 60 Tablets is categorized by the FDA as for research-purposes-only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. The information above summarizes effects observed in laboratory studies to date and is provided strictly for scientific and educational reference.