4X Blend GHRP-2 (5mg) / Tesamorelin (5mg) / MGF (500mcg) / Ipamorelin (2.5mg)
The Science
What is the GHRP-2 / Tesamorelin / MGF / Ipamorelin Blend?
This 4X blend stacks two distinct ghrelin secretagogues (GHRP-2 and Ipamorelin), a stabilized GHRH analog (Tesamorelin), and Mechano Growth Factor (MGF, the IGF-1Ec splice variant).
GHRP-2 is a stronger ghrelin receptor agonist than Ipamorelin and produces a larger GH pulse, but it carries some non-selective hormonal activity (mild cortisol and prolactin elevation). Pairing GHRP-2 with Ipamorelin lets researchers study cross-effects of two GHS-R1a ligands with different selectivity profiles.
Tesamorelin provides the GHRH-axis component, and MGF contributes a localized IGF-1 signal—producing a composite blend covering systemic GH release, hepatic IGF-1 elevation, and tissue-localized repair signaling.
Laboratory Observations
Key Observed Effects in Research
Maximal GH Amplitude
Layered ghrelin and GHRH signals produce the largest combined GH pulse of the 2X/3X/4X blend series.
Composite Anabolic Profile
Combines systemic GH release with local muscle satellite cell signaling.
Visceral Adipose Pathway
Tesamorelin component preserves its VAT-reduction signature.
Investigational Stacking
Allows research into receptor crosstalk between two ghrelin agonists of differing selectivity.
Mechanism of Action
Layered Multi-Receptor Stimulation
Two ghrelin agonists, a GHRH analog, and a local IGF-1 splice variant act through parallel pathways relevant to GH release and repair signaling.
Strong Ghrelin Pulse
GHRP-2 drives the dominant GHS-R1a activation.
Selective Ghrelin Co-Stimulus
Ipamorelin contributes a clean ghrelin signal.
GHRH Axis
Tesamorelin activates pituitary GHRH receptors with extended plasma exposure.
Local IGF-1 Signal
MGF supports satellite cell activation at the local administration site.
FAQ
Frequently Asked Questions
Why pair GHRP-2 with Ipamorelin?+
They are both ghrelin receptor agonists but with different selectivity profiles. Stacking them lets researchers investigate receptor saturation, cross-effects, and combined GH pulse amplitude.
Research-Only Notice
4X Blend GHRP-2 (5mg) / Tesamorelin (5mg) / MGF (500mcg) / Ipamorelin (2.5mg) is categorized by the FDA as for research-purposes-only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. The information above summarizes effects observed in laboratory studies to date and is provided strictly for scientific and educational reference.