2X Blend CJC-1295 No DAC (10mg) / Ipamorelin (10mg)
The Science
What is the CJC-1295 / Ipamorelin 5/5 Blend?
CJC-1295 (without DAC), also known as Mod GRF 1-29, is a 30-amino-acid analog of growth hormone-releasing hormone (GHRH). Its short half-life (~30 minutes) produces a discrete pituitary GH pulse without prolonged elevation.
Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist. Unlike older secretagogues, it stimulates GH release without significantly elevating cortisol, prolactin, or aldosterone in laboratory models.
Combining a GHRH analog with a ghrelin mimetic acts on two parallel pituitary pathways, and laboratory studies have shown the combination produces greater amplitude GH pulses than either compound alone.
Laboratory Observations
Key Observed Effects in Research
Amplified GH Pulse
Combination produces greater GH peak amplitude than either monomer in pituitary cell assays.
Preserved Rhythm
Short half-life formulation maintains the pulsatile GH pattern observed under physiological conditions.
Selective Action
Minimal off-target hormonal effects in laboratory studies.
IGF-1 Pathway
Sustained GH pulses translate to downstream hepatic IGF-1 production in animal models.
Mechanism of Action
Dual-Pathway GH Stimulation
CJC-1295 amplifies the GHRH signal while Ipamorelin engages the ghrelin receptor, producing a synergistic—not merely additive—GH release pulse.
GHRH Receptor Activation
CJC-1295 binds pituitary GHRH receptors, increasing cAMP signaling and somatotroph GH transcription.
Ghrelin Receptor Activation
Ipamorelin agonizes GHS-R1a, mobilizing intracellular calcium and amplifying somatotroph response to GHRH.
Selective Profile
Ipamorelin's receptor selectivity avoids the cortisol and prolactin elevation seen with earlier secretagogues such as GHRP-6.
Pulsatile Pattern
The short half-lives of both peptides preserve the natural pulsatile GH rhythm critical for downstream IGF-1 signaling.
FAQ
Frequently Asked Questions
How does this differ from CJC-1295 with DAC?+
The no-DAC version lacks the Drug Affinity Complex modification, giving it a short (~30 min) half-life and a discrete GH pulse rather than the sustained 'bleed' produced by the DAC-modified analog.
Research-Only Notice
2X Blend CJC-1295 No DAC (10mg) / Ipamorelin (10mg) is categorized by the FDA as for research-purposes-only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. The information above summarizes effects observed in laboratory studies to date and is provided strictly for scientific and educational reference.