ARA-290 (14mg)
Cibinetide / EPO Analog
ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the helix B domain of erythropoietin (EPO). Unlike EPO, it does not affect red blood cell production but retains powerful tissue-protective and anti-inflammatory properties.
The Science
What is ARA-290?
ARA-290 is a synthetic peptide engineered to mimic the tissue-protective effects of erythropoietin without the hematopoietic (red blood cell stimulating) effects that limit EPO's clinical utility.
It binds to the innate repair receptor (IRR), a heteromer of the EPO receptor and CD131, which is upregulated in injured and inflamed tissues. This selective binding produces anti-inflammatory and pro-repair effects.
Research has focused on diabetic neuropathy, sarcoidosis-related small fiber neuropathy, chronic neuropathic pain, and tissue injury repair.
Laboratory Observations
Key Observed Effects of ARA-290 (14mg)
Neuropathy Support
Researched for diabetic and sarcoidosis-related small fiber neuropathy.
Pain Reduction
May reduce chronic neuropathic pain by repairing damaged nerve fibers.
Tissue Repair
Promotes repair of inflamed and injured tissues without affecting red blood cell production.
Anti-Inflammatory
Modulates chronic inflammation through innate immune pathways.
Mechanism of Action
Mechanism of Action
ARA-290 activates the innate repair receptor to reduce inflammation and promote tissue regeneration.
Innate Repair Receptor Binding
Selectively binds the IRR expressed on injured cells, triggering pro-survival and anti-inflammatory pathways.
Neuroprotection
Supports nerve fiber repair and reduces neuropathic pain signaling in damaged peripheral nerves.
Anti-Inflammatory Action
Downregulates pro-inflammatory cytokines while promoting resolution of chronic inflammation.
Research-Only Notice
ARA-290 (14mg) is categorized by the FDA as for research-purposes-only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. The information above summarizes effects observed in laboratory studies to date and is provided strictly for scientific and educational reference.