a-Klotho MAB (10mcg) x 2 vials

Longevity Protein

α-Klotho is a longevity-associated protein involved in regulating aging, mineral metabolism, vascular health, and cognitive function. α-Klotho MAB is a research-grade monoclonal antibody used to study Klotho signaling pathways.

The Science

What is α-Klotho?

Klotho is a protein primarily produced in the kidney and brain that has been shown in research to play a central role in healthy aging. Higher circulating Klotho levels are associated with improved cardiovascular, renal, and cognitive function.

α-Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) and modulates phosphate/calcium balance, oxidative stress, and insulin/IGF-1 signaling—pathways tightly linked to longevity.

α-Klotho MAB is a monoclonal antibody used in research settings to investigate Klotho biology, age-related decline, and tissue protection mechanisms.

Laboratory Observations

Key Observed Effects of a-Klotho MAB (10mcg) x 2 vials

Longevity Research

Supports investigations into one of the most studied longevity-associated proteins.

Vascular Protection

Klotho signaling is linked to endothelial function and arterial health.

Cognitive Health

Higher Klotho levels are associated with preserved cognitive function in aging populations.

Renal Function

Klotho is heavily expressed in the kidney and supports renal protective pathways.

Mechanism of Action

α-Klotho influences several pathways central to healthy aging and tissue maintenance.

FGF23 Co-Receptor

Acts as a co-receptor for FGF23, regulating phosphate balance and vitamin D metabolism critical to vascular and skeletal health.

Anti-Oxidative Signaling

Suppresses oxidative stress pathways and supports mitochondrial function, protecting cells from age-related damage.

IGF-1/Insulin Modulation

Modulates insulin and IGF-1 signaling, pathways consistently linked to lifespan extension in research models.

Research-Only Notice

a-Klotho MAB (10mcg) x 2 vials is categorized by the FDA as for research-purposes-only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. The information above summarizes effects observed in laboratory studies to date and is provided strictly for scientific and educational reference.